Green Synthesis of Selenium Nanoparticles: Characterization and Therapeutic Applications in Microbial and Cancer Treatments

Yasodha S; Vickram A.S; Rajeshkumar S

doi:10.54392/irjmt2432

Authors

Yasodha S Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-602105, Tamil Nadu, India Author https://orcid.org/0009-0001-8861-4802
Vickram A.S Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-602105, Tamil Nadu, India Author
Rajeshkumar S Nanobiomedicine Lab, Centre for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai-602105, Tamil Nadu, India Author https://orcid.org/0000-0001-7059-8894

DOI:

https://doi.org/10.54392/irjmt2432

Keywords:

Selenium, Nanoparticles, Anticancer, Therapeutic, Antibacterial, Antioxidant

Abstract

Selenium is one of these micronutrients that are essential for animals, plants and microorganisms to remain functional. This review is about the green synthesis of selenium nanoparticles and its application in microbial and cancer therapies. Our hypothesis was that Se NPs produced using plant extracts might offer the biocompatibility and environmental friendliness advantages, and hence be a new prospect for medical applications. To test our hypothesis, we conducted a comprehensive analysis of recent literature, exploring various green synthesis conditions and processes for Se NPs. Various characterisation techniques such as spectroscopy, microscopy and physicochemistry were discussed in order to provide insight into the formation and function of green-synthesised Se NPs. Our findings show that Se NPs produced by green chemistry methods have good properties such as uniform size, shape and stability as detailed examples from recent studies reveal. Furthermore, we discussed the therapeutic and theranostic applications of Se NPs produced in this manner: their potential in antimicrobial and anticancer treatments. Through illustrations of cases where Se NPs inhibit microbial growth and cause apoptosis in cancer cells, the practical significance of our findings was underscored. In summary, our review affirms that using green-mediated synthesis Se NPs improves their biocompatibility and therapeutic efficacy, thus opening up new realms for their application in medical research.

References

Z.K. Amirhosseini, R. Monsef, S.A. Ehsanizadeh, W.K.Y. Albahadly, H.S. Majdi, A.A. Amir, A.H. Dawood, M. Salavati-Niasari, Tailoring the photocatalytic activity of novel magnetically separable ZnFe12O19-chitosan bionanocomposites: A green preparation, structural characterization and comparative study. International Journal of Hydrogen Energy, 48(95), (2023) 37286-37301. https://doi.org/10.1016/j.ijhydene.2023.06.130

K.K. Karthik, B.V. Cheriyan, S. Rajeshkumar, M. Gopalakrishnan, A review on selenium nanoparticles and their biomedical applications. Biomedical Technology, 6, (2024) 61-74. https://doi.org/10.1016/j.bmt.2023.12.001

H. Teymourinia, M. Salavati-Niasari, O. Amiri, H. Safardoust-Hojaghan, Synthesis of graphene quantum dots from corn powder and their application in reduce charge recombination and increase free charge carriers. Journal of Molecular Liquids, 242, (2017) 447–455. https://doi.org/10.1016/j.molliq.2017.07.052

D. Vicente-Zurdo, N. Rosales-Conrado, M.E. León-González, Unravelling the in vitro and in vivo potential of selenium nanoparticles in Alzheimer’s disease: A bioanalytical review. Talanta, 269, (2024) 125519. https://doi.org/10.1016/j.talanta.2023.125519

P.B. Nikam, J.D. Salunkhe, T. Minkina, V.D. Rajput, B.S. Kim, S.V. Patil, A review on green synthesis and recent applications of red nano Selenium. Results in Chemistry, 4, (2022) 100581. https://doi.org/10.1016/j.rechem.2022.100581

M. Ashengroph S. Tozandehjani, Optimized resting cell method for green synthesis of selenium nanoparticles from a new Rhodotorula mucilaginosa strain. Process Biochemistry, 116, (2022) 197–205. https://doi.org/10.1016/j.procbio.2022.03.014

M. Salavati-Niasari, Ship-in-a-bottle synthesis, characterization and catalytic oxidation of styrene by host (nanopores of zeolite-Y)/guest ([bis(2-hydroxyanil)acetylacetonato manganese(III)]) nanocomposite materials (HGNM). Microporous and mesoporous materials, 95(1-3), (2006) 248- 256. https://doi.org/10.1016/j.micromeso.2006.05.025

D. Antony, K. Balasubramanian, R. Yadav, Experimental and computational studies of phytomediated selenium-CuO and ZnO nanoparticles-potential drugs for breast cancer, Journal of Molecular Structure, 1263, (2022) 133113. https://doi.org/10.1016/j.molstruc.2022.133113

I.H. Ifijen, M. Maliki, B. Anegbe, Synthesis, photocatalytic degradation and antibacterial properties of selenium or silver doped zinc oxide nanoparticles: A detailed review. Open Nano, 8, (2022) 100082. https://doi.org/10.1016/j.onano.2022.100082

C. Qian, X. Dong, S. A. Hussain, L. Wang, G. Zhao, The application of silver nanoparticles green-formulated by Origanum majorana leaf extract as a hydrazine sensor and treatment of human breast cancer by following the P53 and STAT3 signaling pathways, Journal of Science: Advanced Materials and Devices, 9(2), (2024) 100691. https://doi.org/10.1016/j.jsamd.2024.100691

M. Salavati-Niasari, M. Dadkhah, F. Davar, Pure cubic ZrO2 nanoparticles by thermolysis of a new precursor. Polyhedron, 28(14), (2009) 3005–3009. https://doi.org/10.1016/j.poly.2009.06.032

T. Deepa, S. Mohan, and P. Manimaran, A crucial role of selenium nanoparticles for future perspectives. Results in Chemistry, 4, (2022) 100367. https://doi.org/10.1016/j.rechem.2022.100367

M. Panahi-Kalamuei, M. Salavati-Niasari, S.M. Hosseinpour-Mashkani, Facile microwave synthesis, characterization, and solar cell application of selenium nanoparticles. Journal of alloys and compounds 617, (2014) 627-632. https://doi.org/10.1016/j.jallcom.2014.07.174

X. Zhang, M. Zhong, R. Zhou, W. Qin, Y. Si, Se(IV) reduction and extracellular biosynthesis of Nano-Se(0) by Shewanella oneidensis MR-1 and Shewanella putrefaciens. Process Biochemistry, 130, (2023) 481–491. https://doi.org/10.1016/j.procbio.2023.05.016

H. Khojasteh, M. Salavati-Niasari, H. Safajou, H. Safardoust-Hojaghan, Facile reduction of graphene using urea in solid phase and surface modification by N-doped graphene quantum dots for adsorption of organic dyes. Diamond and Related Materials, 79, (2017) 133–144. https://doi.org/10.1016/j.diamond.2017.09.011

Y. Chen, J. Hua, Y. Ling, Y. Liu, M. Chen, B. Ju, W. Gao, A. Mills, X. Tao, R. Yin, An airflow-driven system for scalable production of nano-microfiber wrapped triboelectric yarns for wearable applications. Chemical Engineering Journal, 477, (2023) 147026. https://doi.org/10.1016/j.cej.2023.147026

K. Rajabi, E. Pakizeh, H. Tashakori, F. Taghizadeh-Farahmand, First principle analysis of the structural, electrical and thermoelectric properties of YTe (YSi, Pb, Sn, Ge) and PbX (X= O, S, Se, Te) nano-layers. Solid State Communications, 359, (2023) 115023. https://doi.org/10.1016/j.ssc.2022.115023

H. Yu, P. Miao, D. Li, Y. Wu, C. Zhou, C. Pan, Improving red pitaya fruit quality by nano- selenium biofortification to enhance phenylpropanoid and betalain biosynthesis. Ecotoxicology and Environmental Safety, 267, (2023) 115653. https://doi.org/10.1016/j.ecoenv.2023.115653

Y. Jiang, B. Dong, X. Jiao, J. Shan, C. Fang, K. Zhang, D. Li, C. Xu, Z. Zhang, Nano-selenium alleviates the pyroptosis of cardiovascular endothelial cells in chicken induced by decabromodiphenyl ether through ERS-TXNIP- NLRP3 pathway. Science of The Total Environment, 915, (2024) 170129. https://doi.org/10.1016/j.scitotenv.2024.170129

C. Krishnaraj, S. Radhakrishnan, M. Mengistu Asmare, S. Wahab, B.-S. Kim, S.-I. Yun, Green synthesis of Ag and Au NPs decorated rGO nanocomposite for high impedimetric electrochemical sensor as well as enhanced antimicrobial performance against foodborne pathogens. Arabian Journal of Chemistry, 17(1), (2024) 105379. https://doi.org/10.1016/j.arabjc.2023.105379

R. Xie, J. Zhou, T. Wang, Y. Xu, B. Zhang, S. Negm, A.F. Elkott, Design and synthesis of chitosan/calcium lignosulfonate/Au NPs: Its performance for reduction of nitro compounds and in the treatment of cancer. Arabian Journal of Chemistry, 17(4), (2024) 105709. https://doi.org/10.1016/j.arabjc.2024.105709

Y. Gao, H. Dou, Y. Ma, G. Tian, D.M. Weragoda, S. Li, X. Yang, Z. Zhang, G. Fan, B. Chen, Antibacterial performance effects of Ag NPs in situ loaded in MOFs nano-supports prepared by post-synthesis exchange method. Journal of Environmental Chemical Engineering, 12(2), 112133 (2024) 112133. https://doi.org/10.1016/j.jece.2024.112133

Y. Song, F. Yang, B. Mu, M. Ma, Z. Quan, A. Wang, Green synthesis of selenium/attapulgite nanocomposites and antibacterial activities evaluation. Cleaner Materials, 9, (2023) 100197. https://doi.org/10.1016/j.clema.2023.100197

K.K. Brar, S. Magdouli, A. Othmani, J. Ghanei, V. Narisetty, R. Sindhu, P. Binod, A. Pugazhendhi, M.K. Awasthi, A. Pandey, Green route for recycling of low-cost waste resources for the biosynthesis of nanoparticles (NPs) and nanomaterials (NMs)-A review. Environmental Research, 207, (2022) 112202. https://doi.org/10.1016/j.envres.2021.112202

I.A. Shaikh, B. Turakani, M.H. Mahnashi, A.S. Alqahtani, S.H. Hariri, M.M Ghoneim, H.A. Ebrahim, M. El-Sherbiny, B.A. Mannasaheb, U.M. Muddapur, G. Khuwaja, environmentally friendly production, characterization, and evaluation of ZnO NPs from Bixa orellana leaf extract and assessment of its antimicrobial activity,” Journal of King Saud University- Science, 35(11), (2023) 102957. https://doi.org/10.1016/j.jksus.2023.102957

C. Ragavendran, C. Kamaraj, A.F. Alrefaei, A. Priyadharsan, L.P. de Matos, G. Malafaia, A. Moulishankar, S. Thirugnanasambandam Green- route synthesis of ZnO nanoparticles via Solanum surattense leaf extract: Characterization, biomedical applications and their ecotoxicity assessment of zebrafish embryo model. South African Journal of Botany, 167, (2024) 643-662. https://doi.org/10.1016/j.sajb.2024.02.049

T. Govindasamy, N.K. Mathew, V.K. Asapu, V. Subramanian, B. Subramanian, Modulating the structural and magnetic properties of Fe3O4 NPs for high-performance supercapattery and EMI shielding applications. Journal of Energy Storage, 79, (2024) 110243. https://doi.org/10.1016/j.est.2023.110243

M. Zeeshan, Y.X. Hu, A. Iqbal, A. Salam, Y.X Liu, I. Muhammad, S. Ahmad, A.H. Khan, B. Hale, H.Y. Wu, X.B. Zhou, Amelioration of AsV toxicity by concurrent application of ZnO-NPs and Se- NPs is associated with differential regulation of photosynthetic indexes, antioxidant pool and osmolytes content in soybean seedling. Ecotoxicology and Environmental Safety, 225, (2021) 112738. https://doi.org/10.1016/j.ecoenv.2021.112738

A. V Tugarova, P. V Mamchenkova, V. A. Khanadeev, A. A. Kamnev, Selenite reduction by the rhizobacterium Azospirillum brasilense, synthesis of extracellular selenium nanoparticles and their characterisation, New biotechnology, 58, (2020) 17-24. https://doi.org/10.1016/j.nbt.2020.02.003

M. S. AlSalhi, G. Oza, I. Castillo-Maldonado, A. Sharma, Evaluation of antimicrobial, antioxidant, and anti-inflammatory abilities of sustainably synthesized Co3O4 NPs. Biocatalysis and Agricultural Biotechnology, 56, (2024), 103025. https://doi.org/10.1016/j.bcab.2024.103025

K. C. Nwoko, X. Liang, M. A. M. J. Perez, E. Krupp, G. M. Gadd, J. Feldmann, Characterisation of selenium and tellurium nanoparticles produced by Aureobasidium pullulans using a multi-method approach, Journal of Chromatography A, 1642, (2021) 462022. https://doi.org/10.1016/j.chroma.2021.462022

C. S. Diko, Y. Qu, Z. Henglin, Z. Li, N. Ahmed Nahyoon, S. Fan, Biosynthesis and characterization of lead selenide semiconductor nanoparticles (PbSe NPs) and its antioxidant and photocatalytic activity. Arabian Journal of Chemistry, 13(11), (2020) 8411-8423. https://doi.org/10.1016/j.arabjc.2020.06.005

F. Azimi, M. Oraei, G. Gohari, S. Panahirad, A. Farmarzi, Chitosan-selenium nanoparticles (Cs– Se NPs) modulate the photosynthesis parameters, antioxidant enzymes activities and essential oils in Dracocephalum moldavica L. under cadmium toxicity stress. Plant Physiology and Biochemistry, 167, (2021) 257-268. https://doi.org/10.1016/j.plaphy.2021.08.013

Y. Song, F. Yang, M. Ma, Y. Kang, A. Hui, Z. Quan, A. Wang, Green synthesized Se– ZnO/attapulgite nanocomposites using Aloe vera leaf extract: Characterization, antibacterial and antioxidant activities. LWT, 165, (2022) 113762. https://doi.org/10.1016/j.lwt.2022.113762

K. Saravanakumar, Z. Li, Y. Kim, S. Park, K. Keon, C.M. Lee, G. Ahn, N. Cho, Fucoidan- coated cotton dressing functionalized with biomolecules capped silver nanoparticles (LB-Ag NPs–FN–OCG) for rapid healing therapy of infected wounds, Environmental Research, 246, (2024) 118004. https://doi.org/10.1016/j.envres.2023.118004

A.M.A. El-Seidy, M.A. Elbaset, F.A.A. Ibrahim, S.A. Abdelmottaleb Moussa, S.A.E. Bashandy, Nano cerium oxide and cerium/zinc nanocomposites characterization and therapeutic role in combating obesity via controlling oxidative stress and insulin resistance in rat model. Journal of Trace Elements in Medicine and Biology, 80, (2023) 127312. https://doi.org/10.1016/j.jtemb.2023.127312

Y. Wang, J. Wu, M. Chen, J. Zhang, X. Sun, H. Zhou, Z. Gao, Application of near-infrared- activated and ATP-responsive trifunctional upconversion nano-jelly for in vivo tumor imaging and synergistic therapy. Biosensors and Bioelectronics, 250, (2024) 116094. https://doi.org/10.1016/j.bios.2024.116094

S. Parveen, S. Kumar, S. Pal, N. P. Yadav, J. Rajawat, M. Banerjee, enhanced therapeutic efficacy of Piperlongumine for cancer treatment using nano-liposomes mediated delivery. International Journal of Pharmaceutics, 643, (2023) 123212. https://doi.org/10.1016/j.ijpharm.2023.123212

D. Yang, Y. Han, Y. Wang, Y. Pan, L. Zheng, Z, Liu, C. Li, Y. Wu, H. Li, Highly effective corneal permeability of reactive oxygen species- responsive nano-formulation encapsulated cyclosporine a for dry eye management. Chemical Engineering Journal, 469, (2023) 143968. https://doi.org/10.1016/j.cej.2023.143968

Y. Liu, Q. Guo, H. Sun, N. Guo, J. Zhang, Improved therapeutic efficiency of photothermal treatment and nursing care in prostate cancer by DOX loaded PEG coated Cu@Se nano-hybrid vesicle. Process biochemistry, 92, (2020) 78-84. https://doi.org/10.1016/j.procbio.2020.02.022

J. Li, Q. Sun, L. Sun, X. Fu, G. Deng, Z. Li, Fabrication of pH-responsive co-delivery system for nano selenium and doxorubicin with PEGylated chitosan: Effect of PEGylation. Journal of Drug Delivery Science and Technology, 86, (2023) 104706. https://doi.org/10.1016/j.jddst.2023.104706

F. Mpekris, M. Panagi, A. Charalambous, C. Voutouri, C. Michael, A. Papoui, T.A. Stylianopoulos, synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas. Neoplasia, 51, (2024) 100990. https://doi.org/10.1016/j.neo.2024.100990

D.M. Mohammed, N. Elsayed, D.H. Abou Baker, K.A. Ahmed, B.A. Sabry, Bioactivity and antidiabetic properties of Malva parviflora L. leaves extract and its nano-formulation in streptozotocin-induced diabetic rats. Heliyon, 8(12), (2022) e12027. https://doi.org/10.1016/j.heliyon.2022.e12027

K.S. Alotaibi, M. Elobeid, P. Virk, M.A. Awad, M.A., Al-Qahtani, D.M. Elnagar, Plausible effect of hesperetin and nano-hesperetin against bisphenol-A induced hepatoxicity in a rat model. Arabian Journal of Chemistry, 17(2), (2024) 105563. https://doi.org/10.1016/j.arabjc.2023.105563

S. Sun, w. Feng, Z. Chen, Z. Huang, X. Mu, Y. Lu, X. Zhou, Engineering thio-/seleno-ether linkers into zwitterionic small molecule nano- prodrugs for traceable cancer theranostics. Sensors Actuators B Chemical, 387, (2023) 133771. https://doi.org/10.1016/j.snb.2023.133771

C. Liang, G. Zhang, L. Guo, X. Ding, H. Yang, H. Zhang, Z. Zhang, L. Hou, Spatiotemporal transformable nano-assembly for on-demand drug delivery to enhance anti-tumor immunotherapy, Asian Journal of Pharmaceutical Sciences, 19(1), (2024) 100888. https://doi.org/10.1016/j.ajps.2024.100888

V. Tavallali, Z. Shabanpisheh, H. Gholami, F. M. Abarghuei, Modifications in Lemongrass (Cymbopogon spp.) in response to green synthesized nano-selenium complex, Scientia Horticulturae, 303, (2022) 111222. https://doi.org/10.1016/j.scienta.2022.111222

Y.-M. Yu, F.-Z. Bu, S.-S. Meng, C.-W. Yan, Z.-Y. Wu, Y.-T. Li, The first nano-cocrystal formulation of marine drug cytarabine with uracil based on cocrystal nanonization strategy for long-acting injection exhibiting enhanced antitumor activity. International Journal of Pharmaceutics, 644, (2023) 123300. https://doi.org/10.1016/j.ijpharm.2023.123300

S. Lin, Y. Zhu, T. Hu, K. Wang, X. Chen, Novel design of nano-selenium loaded injectable hydrogel combined with mesenchymal stem cells-derived exosomes improving cardiac repair and nursing care after acute myocardial infarction. Journal of Drug Delivery Science and Technology, 87, (2023) 104711. https://doi.org/10.1016/j.jddst.2023.104711

M. Wang, Y. Zhou, Z. Wang, Unearth the ultrapotent intrinsic fungicidal efficacy of the surface-piercing CuFeSe2-PVP nano-blade. Chemical Engineering Journal, 464, (2023) 142603. https://doi.org/10.1016/j.cej.2023.142603

M. Bartkowski, V. Bincoletto, I.C. Salaroglio, G. Ceccone, R. Arenal, S. Nervo, B. Rolando, C. Riganti, S. Arpicco, S. Giordani, Enhancing pancreatic ductal adenocarcinoma (PDAC) therapy with targeted carbon nano-onion (CNO)- mediated delivery of gemcitabine (GEM)-derived prodrugs. Journal of Colloid and Interface Science, 659, (2024) 339-354. https://doi.org/10.1016/j.jcis.2023.12.166

A. Hać, D. Milaș, F. Dziubek, M. Łomeć, A. Herman-Antosiewicz, K. Żamojć, Searching for relationships between the structure of selected simple coumarins, their antioxidant capacity and anticancer properties. Journal of Molecular Structure, 1294, (2023) 136477. https://doi.org/10.1016/j.molstruc.2023.136477

D. Yan, J. Arakelyan, T. Wan, R. Raina, T.K. Chan, D. Ahn, V. Kushnarev, T.K. Cheung, H.C. Chan, I. Choi, P.Y. Ho, Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties. Acta Pharmaceutica Sinica B, 14(1), (2024) 421-432. https://doi.org/10.1016/j.apsb.2023.08.025

S. Alyar, H. Alyar, Ü. Özdemir Özmen, O. Aktaş, K. Erdem, Biochemical properties of Schiff bases derived from FDA-approved sulfa drugs: Synthesis, ADME/molecular docking studies, and anticancer activity. Journal of Molecular Structure, 1293, (2023) 136167. https://doi.org/10.1016/j.molstruc.2023.136167

F. Esmaeili, M. Farhadpour, M. Abbas- Mohammadi, M. Alilou, D. Morshedi, E. Ebrahimie, T. Lohrasebi, Appraisals on the anticancer properties of Mentha species using bioassays and docking studies. Industrial Crops and Products, 203, (2023) 117128. https://doi.org/10.1016/j.indcrop.2023.117128

Z.M. Alaizeri, H.A. Alhadlaq, S. Aldawood, M. ALSaeedy, M.K. Gatasheh, Tuning The physicochemical Properties of CeO2 Nanoparticles for Enhanced Photocatalytic and Anticancer Performance by Zn Doping, Journal of Radiation Research and Applied Sciences, 17(2), (2024) 100889. https://doi.org/10.1016/j.jrras.2024.100889

E. Papadopoulou, F. Bekris, S. Vasileiadis, A. Krokida, T. Rouvali, A.S. Veskoukis, K. Liadaki, D. Kouretas, D.G. Karpouzas, Vineyard- mediated factors are still operative in spontaneous and commercial fermentations shaping the vinification microbial community and affecting the antioxidant and anticancer properties of wines. Food Research International, 173, (2023) 113359. https://doi.org/10.1016/j.foodres.2023.113359

D. Shen, S. Kang, Ultrasonic-assisted hydrothermal fabrication of selenium nanorods and their anticancer properties in prostate cancer cells and associated signaling pathway. Arabian Journal of Chemistry, (2024) 105714. https://doi.org/10.1016/j.arabjc.2024.105714

N. Dobrovolskienė, R. Balevičius, A. Mlynska, K. Žilionytė, J.A. Krasko, M. Strioga, I. Lieknina, D. Pjanova, V, Pašukonienė, Immunomodulatory properties of bacteriophage derived dsRNA of different size and their use as anticancer vaccine adjuvants. Vaccine, 42(3), (2024) 512–521. https://doi.org/10.1016/j.vaccine.2023.12.071

X. Liu, Y. Sun, Q, Li, P. Zhang, R. Tao, J. Chang, S. Zhang, Y. Zhang, Y. Zhang, X.A. Yuan, Z. Liu, Organotin(IV)-tetraphenylethylene acylhydrazone compounds with aggregation- induced emission property and application in anticancer therapy. Dyes and Pigments, 223, (2024) 111963. https://doi.org/10.1016/j.dyepig.2024.111963

M.M. Ghatage, P.A. Mane, R.P. Gambhir, V.S. Parkhe, P.A. Kamble, C.D. Lokhande, A.P. Tiwari, Green synthesis of silver nanoparticles via Aloe barbadensis miller leaves: Anticancer, antioxidative, antimicrobial and photocatalytic properties. Applied Surface Science Advances, 16, (2023) 100426. https://doi.org/10.1016/j.apsadv.2023.100426

T. Nagendraraj, E.A. Noelson, D.S. Soundarya, I. Mani, V. Ragavendran, J. Mayandi, M. Pandi, J. Annaraj, S. Sagadevan, Hybrid TiO2-Ag2O nanocomposites as efficient photocatalysts for the removal of medicinal pollutants in water under sunlight and study on their anticancer properties. Journal of Alloys and Compounds, 982, (2024) 173777. https://doi.org/10.1016/j.jallcom.2024.173777

F. Sharifi, I. Sharifi, Z. Babaei, S. Alahdin, A. Afgar, Bioinformatics evaluation of anticancer properties of GP63 protein-derived peptides on MMP2 protein of melanoma cancer. Journal of Pathology Informatics, 14, (2023) 100190. https://doi.org/10.1016/j.jpi.2023.100190

Z. Zhao, Y. Cao, R. Xu, J. Fang, Y. Zhang, X., Xu, L. Huang, R. Li, Nanoparticles (NPs)-mediated targeted regulation of redox homeostasis for effective cancer therapy. Smart Materials in Medicine, (2024). https://doi.org/10.1016/j.smaim.2024.03.003

Z. Wang, L. Yang, Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy. Pharmacological Research, (2024) 107150. https://doi.org/10.1016/j.phrs.2024.107150

Y. Zhang, H.-Y. Zhang, Z. Jiang, Y.-L. Cui, Q.-S. Wang, Targeted glutamine-decorated chitosan nanoparticles with enhanced synergism of chemotherapeutic and natural medicine for hepatic carcinoma therapy. Materials & Design, 220, (2022) 110842. https://doi.org/10.1016/j.matdes.2022.110842

S. Bhattacharya, S. Bonde, K. Hatware, S. Sharma, M. M. Anjum, R. K. Sahu, Physicochemical characterization, in vitro and in vivo evaluation of chitosan/carrageenan encumbered with Imatinib mesylate- polysarcosine nanoparticles for sustained drug release and enhanced colorectal cancer targeted therapy. International Journal of Biological Macromolecules, 245, (2023) 125529. https://doi.org/10.1016/j.ijbiomac.2023.125529

H. Zhang et al., Boost therapy of hepatocellular carcinoma by amplifying vicious cycle between mitochondrial oxidative stress and endoplasmic reticulum stress via biodegradable ultrasmall nanoparticles and old drug, Nano Today, 46, (2022) 101601. https://doi.org/10.1016/j.nantod.2022.101601

R. Zhu, Q. He, Z. Li, Y. Ren, Y. Liao, Z. Zhang, Q. Dai, C. Wan, S. Long, L. Kong, W. Fan, ROS- cleavable diselenide nanomedicine for NIR- controlled drug release and on-demand synergistic chemo-photodynamic therapy, 153, (2022) 442-452. https://doi.org/10.1016/j.actbio.2022.09.061

L. Karthikeyan, R. Vivek, Synergistic anti-cancer effects of NIR-light responsive nanotherapeutics for chemo-photothermal therapy and photothermal immunotherapy: A combined therapeutic approach. Advances in Cancer Biology-Metastasis, 4, (2022) 100044. https://doi.org/10.1016/j.adcanc.2022.100044

Y. Wang, Z. Li, Y. Hu, J. Liu, M. Guo, H. Wei, S. Zheng, T. Jiang, X. Sun, Z. Ma, Y. Sun, Photothermal conversion-coordinated Fenton- like and photocatalytic reactions of Cu2-xSe-Au Janus nanoparticles for tri-combination antitumor therapy. Biomaterials, 255, (2020) 120167. https://doi.org/10.1016/j.biomaterials.2020.120167

M. Jiang, Q. Liu, Y. Zhang, H. Wang, J. Zhang, M. Chen, Z. Yue, Z., Wang, X. Wei, S. Shi, M. Wang, Construction of magnetic drug delivery system and its potential application in tumor theranostics. Biomedicine & Pharmacotherapy, 154, (2022) 113545. https://doi.org/10.1016/j.biopha.2022.113545

Y. Li, W. Wang, Y. Deng, J. Gao, J. Shi, L. Cai, Antioxidant properties and changes in vitro digestion of the fermented kiwifruit extract prepared by lactic acid bacteria and yeasts. Food Chemistry, 442, (2024) 138416. https://doi.org/10.1016/j.foodchem.2024.138416

T. Elo, V. S. Parihar, A. Bera, F. Javanshour, M. Kellomäki, R. Layek, (2024) Mechanically robust, transparent, and UV-shielding composite of Na- Alginate and maleic acid-functionalized boron nitride nanosheets with improved antioxidant property. Colloids Surfaces B Biointerfaces, 233, (2024) 113641. https://doi.org/10.1016/j.colsurfb.2023.113641

A. Papadaki, M. Alexandri, V. Kachrimanidou, P. Tzora, N. Kopsahelis, Enhancing hydrophobic and antioxidant properties of whey protein films through the inclusion of oil and oleogel sourced from spent coffee grounds. Sustainable Chemistry and Pharmacy, 36, (2023) 101293. https://doi.org/10.1016/j.scp.2023.101293

L. Rui, Y. Li, X. Wu, Y. Wang, X. Xia, Effect of clove essential oil nanoemulsion on physicochemical and antioxidant properties of chitosan film. International Journal of Biological Macromolecules, 263, (2024) 130286. https://doi.org/10.1016/j.ijbiomac.2024.130286

Y. Ji, J. Han, M. Moses, M. Wang, L. Wu, W. Xue, L. Sun, B. Xu, C. Chen, Y. Xiang, X. Huang, The antimicrobial property of JY-1, a complex mixture of Traditional Chinese Medicine, is linked to it abilities to suppress biofilm formation and disrupt membrane permeability. Microbial Pathogenesis, 189, (2024) 106573. https://doi.org/10.1016/j.micpath.2024.106573

Q. Huang, W.Z. Wang, S. Liu, X.G. Jia, L. Xia, F.L. Qin, Q. Wang, Y. Liu, H.J. Li, Green fabrication of carbon dioxide-based polycarbonates with durable antimicrobial properties and UV resistance. Chemical Engineering Journal, 477, (2023) 147107. https://doi.org/10.1016/j.cej.2023.147107

Z. Li, H. Hu, J. Zhou, Q. Wang, L. Zhang, X. Shen, C. Mei, Z. He, Y. Jiang, (2024) Enhancement in mechanical properties, antimicrobial properties and osseointegration ability of porous TC4-5Cu alloys prepared via additive manufacturing, Journal of Materials Research and Technology, 29, (2024) 3011– 3023. https://doi.org/10.1016/j.jmrt.2024.02.007

N. Ehyaeirad, N. Babolanimogadam, M. Dadkhah, L. Rezaie Shirmard, Polylactic acid films incorporated with nanochitosan, nanocellulose, and Ajwain essential oil: Synthesis, characterizations, with in-vitro and in- vivo antimicrobial properties for infected wound healing. Carbohydrate Polymer Technologies and Applications 7, (2024) 100425. https://doi.org/10.1016/j.carpta.2024.100425

M. Khalaj, M.Kamali, T.M. Aminabhavi, M.E.V. Costa, R. Dewil, L. Appels, I. Capela, Sustainability insights into the synthesis of engineered nanomaterials - Problem formulation and considerations. Environmental Research, 220, (2023) 115249. https://doi.org/10.1016/j.envres.2023.115249

P. van de Laar, R. Corvino, A. J. Mooij, H. van Wezep, R. Rosmalen, Custom static analysis to enhance insight into the usage of in-house libraries. Journal of Systems and Software, 212, (2024) 112028. https://doi.org/10.1016/j.jss.2024.112028

A. X. Wang, S. S. Chukova, A. Sporle, B. J. Milne, C. R. Simpson, and B. P. Nguyen, Enhancing public research on citizen data: An empirical investigation of data synthesis using Statistics New Zealand’s Integrated Data Infrastructure. Information Processing and Management, 61(1), (2024) 103558. https://doi.org/10.1016/j.ipm.2023.103558

J. Chen, L. Ding, Y. Yang, Y. Xiang, Active diversification of head-class features in bilateral- expert models for enhanced tail-class optimization in long-tailed classification. Engineering Applications of Artificial Intelligence, 126, (2023) 106982. https://doi.org/10.1016/j.engappai.2023.106982

M. Zahedian Nezhad, A.J.J. Bojnordi, M. Mehraeen, R. Bagheri, J. Rezazadeh, Securing the future of IoT-healthcare systems: A meta- synthesis of mandatory security requirements. Engineering Applications of Artificial Intelligence, 185, (2024) 105379. https://doi.org/10.1016/j.ijmedinf.2024.105379

P.N. Mueller, Attention-enhanced conditional- diffusion-based data synthesis for data augmentation in machine fault diagnosis. Engineering Applications of Artificial Intelligence, 131, (2024) 107696, 2024. https://doi.org/10.1016/j.engappai.2023.107696